Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

BACKGROUND: In preclinical studies the heat shock protein 90 (Hsp90) inhibitor tanespimycin induced down-regulation of checkpoint kinase 1 (Chk1) and other client proteins as well as increased sensitivity of acute leukemia cells to cytarabine. We report here the results of a phase I and pharmacologi...

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Hauptverfasser: Kaufmann, Scott H., Karp, Judith E., Litzow, Mark R., Mesa, Ruben A., Hogan, William, Steensma, David P., Flatten, Karen S., Loegering, David A., Schneider, Paula A., Peterson, Kevin L., Maurer, Matthew J., Smith, B. Douglas, Greer, Jacqueline, Chen, Yuhong, Reid, Joel M., Ivy, S. Percy, Ames, Matthew M., Adjei, Alex A., Erlichman, Charles, Karnitz, Larry M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2011
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208679/
https://ncbi.nlm.nih.gov/pubmed/21791475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.049551
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