Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q− syndrome

Large chromosomal deletions are among the most common molecular abnormalities in cancer, yet the identification of relevant genes has proven difficult. The 5q− syndrome, a subtype of myelodysplastic syndrome (MDS), is a chromosomal deletion syndrome characterized by anemia and thrombocytosis. Althou...

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Bibliographic Details
Main Authors: Kumar, Madhu S., Narla, Anupama, Nonami, Atsushi, Mullally, Ann, Dimitrova, Nadya, Ball, Brian, McAuley, J. Randall, Poveromo, Luke, Kutok, Jeffrey L., Galili, Naomi, Raza, Azra, Attar, Eyal, Gilliland, D. Gary, Jacks, Tyler, Ebert, Benjamin L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208282/
https://ncbi.nlm.nih.gov/pubmed/21873545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324715
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