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Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

Human induced pluripotent stem cells (iPSCs) bearing monogenic mutations have great potential for modeling disease phenotypes, screening candidate drugs, and cell replacement therapy provided the underlying disease-causing mutation can be corrected. Here, we report a homologous recombination-based a...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Zou, Jizhong, Mali, Prashant, Huang, Xiaosong, Dowey, Sarah N., Cheng, Linzhao
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208277/
https://ncbi.nlm.nih.gov/pubmed/21881051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-335554
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