Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease–mediated safe harbor targeting

We have developed induced pluripotent stem cells (iPSCs) from a patient with X-linked chronic granulomatous disease (X-CGD), a defect of neutrophil microbicidal reactive oxygen species (ROS) generation resulting from gp91(phox) deficiency. We demonstrated that mature neutrophils differentiated from...

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Detalles Bibliográficos
Autores principales: Zou, Jizhong, Sweeney, Colin L., Chou, Bin-Kuan, Choi, Uimook, Pan, Jason, Wang, Hongmei, Dowey, Sarah N., Cheng, Linzhao, Malech, Harry L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Plenary Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110021/
https://ncbi.nlm.nih.gov/pubmed/21411759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-328161
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