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Chromosome missegregation in human cells arises through specific types of kinetochore–microtubule attachment errors
Most solid tumors are aneuploid, and many missegregate chromosomes at high rates in a phenomenon called chromosomal instability (CIN). CIN reflects the erosion of mitotic fidelity, and it correlates with poor patient prognosis and drug resistance. The most common mechanism causing CIN is the persist...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207692/ https://ncbi.nlm.nih.gov/pubmed/21997207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109720108 |
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