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Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells

Faithful chromosome segregation is required for cell and organism viability and relies on both the mitotic checkpoint and the machinery that corrects kinetochore-microtubule (k-MT) attachment errors [1–3]. Most solid tumors have aneuploid karyotypes and many mis-segregate chromosomes at high rates i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kabeche, Lilian, Compton, Duane A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326208/
https://ncbi.nlm.nih.gov/pubmed/22405866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.02.030
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