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Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells
Faithful chromosome segregation is required for cell and organism viability and relies on both the mitotic checkpoint and the machinery that corrects kinetochore-microtubule (k-MT) attachment errors [1–3]. Most solid tumors have aneuploid karyotypes and many mis-segregate chromosomes at high rates i...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326208/ https://ncbi.nlm.nih.gov/pubmed/22405866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.02.030 |
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