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STAG2 promotes error correction in mitosis by regulating kinetochore–microtubule attachments
Mutations in the STAG2 gene are present in ∼20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss-of-function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes during anaphase. Lagging chromosomes ar...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The Company of Biologists
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4179491/ https://ncbi.nlm.nih.gov/pubmed/25074805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.151613 |
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