Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing

New protein functions can require complex sequence changes, but the minimal path is not well understood. The guanylate kinase enzyme (GK(enz)), which catalyzes phosphotransfer from ATP to GMP, evolved into the GK domain (GK(dom)), a protein-binding domain found in membrane associate guanylate kinase...

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Detaylı Bibliyografya
Asıl Yazarlar: Johnston, Christopher A., Whitney, Dustin S., Volkman, Brian F., Doe, Chris Q., Prehoda, Kenneth E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207680/
https://ncbi.nlm.nih.gov/pubmed/21990344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104365108
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