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The Ca(2+)-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca(2+), Whereas the ATPase E(2) State Remains Functional

Several clotrimazole (CLT) and 4-aminoquinoline derivatives were synthesized and found to exhibit in vitro antiplasmodial activity with IC(50) ranging from nm to μm values. We report here that some of these compounds produce inhibition of rabbit sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1) with IC(...

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Autori principali: Bartolommei, Gianluca, Tadini-Buoninsegni, Francesco, Moncelli, Maria Rosa, Gemma, Sandra, Camodeca, Caterina, Butini, Stefania, Campiani, Giuseppe, Lewis, David, Inesi, Giuseppe
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207476/
https://ncbi.nlm.nih.gov/pubmed/21914795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.287276
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