Ca(2+) Influx through Reverse Mode Na(+)/Ca(2+) Exchange Is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells

VEGF is a key angiogenic cytokine and a major target in anti-angiogenic therapeutic strategies. In endothelial cells (ECs), VEGF binds VEGF receptors and activates ERK1/2 through the phospholipase γ (PLCγ)-PKCα-B-Raf pathway. Our previous work suggested that influx of extracellular Ca(2+) is require...

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Autores principales: Andrikopoulos, Petros, Baba, Akemichi, Matsuda, Toshio, Djamgoz, Mustafa B. A., Yaqoob, Muhammad M., Eccles, Suzanne A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207468/
https://ncbi.nlm.nih.gov/pubmed/21873429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.251777
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