Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca(2+) Influx through the Na(+)/Ca(2+) Exchanger

Thrombin acts on the endothelium by activating protease-activated receptors (PARs). The endothelial thrombin-PAR system becomes deregulated during pathological conditions resulting in loss of barrier function and a pro-inflammatory and pro-angiogenic endothelial phenotype. We reported recently that...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Andrikopoulos, Petros, Kieswich, Julius, Harwood, Steven M., Baba, Akemichi, Matsuda, Toshio, Barbeau, Olivier, Jones, Keith, Eccles, Suzanne A., Yaqoob, Muhammad M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513102/
https://ncbi.nlm.nih.gov/pubmed/25979335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.628156
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