Characterization of Mg(2+) Inhibition of Mitochondrial Ca(2+) Uptake by a Mechanistic Model of Mitochondrial Ca(2+) Uniporter

Ca(2+) is an important regulatory ion and alteration of mitochondrial Ca(2+) homeostasis can lead to cellular dysfunction and apoptosis. Ca(2+) is transported into respiring mitochondria via the Ca(2+) uniporter, which is known to be inhibited by Mg(2+). This uniporter-mediated mitochondrial Ca(2+)...

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Hlavní autoři: Pradhan, Ranjan K., Qi, Feng, Beard, Daniel A., Dash, Ranjan K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2011
Témata:
Biological Systems and Multicellular Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207172/
https://ncbi.nlm.nih.gov/pubmed/22067144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.09.029
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