Extra-matrix Mg(2+) limits Ca(2+) uptake and modulates Ca(2+) uptake–independent respiration and redox state in cardiac isolated mitochondria

Cardiac mitochondrial matrix (m) free Ca(2+) ([Ca(2+)](m)) increases primarily by Ca(2+) uptake through the Ca(2+) uniporter (CU). Ca(2+) uptake via the CU is attenuated by extra-matrix (e) Mg(2+) ([Mg(2+)](e)). How [Ca(2+)](m) is dynamically modulated by interacting physiological levels of [Ca(2+)]...

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Main Authors: Boelens, Age D., Pradhan, Ranjan K., Blomeyer, Christoph A., Camara, Amadou K. S., Dash, Ranjan K., Stowe, David F.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670670/
https://ncbi.nlm.nih.gov/pubmed/23456198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10863-013-9500-5
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