Slow Ca(2+) Efflux by Ca(2+)/H(+) Exchange in Cardiac Mitochondria Is Modulated by Ca(2+) Re-uptake via MCU, Extra-Mitochondrial pH, and H(+) Pumping by F(O)F(1)-ATPase

Mitochondrial (m) Ca(2+) influx is largely dependent on membrane potential (ΔΨ(m)), whereas mCa(2+) efflux occurs primarily via Ca(2+) ion exchangers. We probed the kinetics of Ca(2+)/H(+) exchange (CHE(m)) in guinea pig cardiac muscle mitochondria. We tested if net mCa(2+) flux is altered during a...

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Udgivet i:Front Physiol
Main Authors: Haumann, Johan, Camara, Amadou K. S., Gadicherla, Ashish K., Navarro, Christopher D., Boelens, Age D., Blomeyer, Christoph A., Dash, Ranjan K., Boswell, Michael R., Kwok, Wai-Meng, Stowe, David F.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378946/
https://ncbi.nlm.nih.gov/pubmed/30804812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01914
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