Extracellular Proton Modulation of the Cardiac Voltage-Gated Sodium Channel, Na(V)1.5

Low pH depolarizes the voltage dependence of voltage-gated sodium (Na(V)) channel activation and fast inactivation. A complete description of Na(V) channel proton modulation, however, has not been reported. The majority of Na(V) channel proton modulation studies have been completed in intact tissue....

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Detalles Bibliográficos
Autores principales: Jones, D.K., Peters, C.H., Tolhurst, S.A., Claydon, T.W., Ruben, P.C.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2011
Materias:
Channels and Transporters
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207155/
https://ncbi.nlm.nih.gov/pubmed/22067152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.08.056
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