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Serine side chain-linked peptidomimetic conjugates of cyclic HPMPC and HPMPA: Synthesis and interaction with hPEPT1
Cidofovir, (HPMPC), a broad spectrum antiviral agent, cannot be administered orally due to ionization of its phosphonic acid group at physiological pH. One prodrug approach involves conversion to the cyclic form (cHPMPC, 1) and esterification by the side chain hydroxyl group of a peptidomimetic seri...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205993/ https://ncbi.nlm.nih.gov/pubmed/20929265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100186b |
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