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Infectious Prion Protein Alters Manganese Transport and Neurotoxicity in a Cell Culture Model of Prion Disease

Protein misfolding and aggregation are considered key features of many neurodegenerative diseases, but biochemical mechanisms underlying protein misfolding and the propagation of protein aggregates are not well understood. Prion disease is a classical neurodegenerative disorder resulting from the mi...

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Détails bibliographiques
Auteurs principaux: Martin, Dustin P., Anantharam, Vellareddy, Jin, Huajun, Witte, Travis, Houk, Robert, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205977/
https://ncbi.nlm.nih.gov/pubmed/21871919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2011.07.008
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