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Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases
Zinc finger nucleases (ZFNs) allow site-specific manipulation of the genome. So far, the use of ZFNs to create gene knockouts has been restricted to protein-coding genes. However, non-protein-encoding RNAs (ncRNA) play important roles in the cell, although the functions of most ncRNAs are unknown. H...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205578/ https://ncbi.nlm.nih.gov/pubmed/21844124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.122358.111 |
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