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Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases

Zinc finger nucleases (ZFNs) allow site-specific manipulation of the genome. So far, the use of ZFNs to create gene knockouts has been restricted to protein-coding genes. However, non-protein-encoding RNAs (ncRNA) play important roles in the cell, although the functions of most ncRNAs are unknown. H...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gutschner, Tony, Baas, Marion, Diederichs, Sven
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205578/
https://ncbi.nlm.nih.gov/pubmed/21844124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.122358.111
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