Structural and Thermodynamic Consequences of the Replacement of Zinc with Environmental Metals on ERα-DNA Interactions

Estrogen receptor α (ERα) acts as a transcription factor by virtue of the ability of its DNA-binding (DB) domain, comprised of a tandem pair of zinc fingers, to recognize the estrogen response element (ERE) within the promoters of target genes. Herein, using an array of biophysical methods, we probe...

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Autores principales: Deegan, Brian J., Bona, Anna M., Bhat, Vikas, Mikles, David C., McDonald, Caleb B., Seldeen, Kenneth L., Farooq, Amjad
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205435/
https://ncbi.nlm.nih.gov/pubmed/22038807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.1148
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