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Distinct PGE(2)-responder and non-responder phenotypes in human mast cell populations: “All or nothing” enhancement of antigen-dependent mediator release

Reports indicate that prostaglandin (PG)E(2) markedly enhances antigen-mediated degranulation in mouse bone marrow-derived mast cells (BMMCs) but not in human mast cells (HuMCs). We have examined the underlying mechanism(s) for this disparity in HuMCs derived from the peripheral blood of multiple do...

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Main Authors: Kuehn, Hye Sun, Jung, Mi-Yeon, Beaven, Michael A., Metcalfe, Dean D., Gilfillan, Alasdair M.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205336/
https://ncbi.nlm.nih.gov/pubmed/21798286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2011.07.002
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