Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane

Diabetes mellitus is associated with platelet hyperactivity, which leads to increased morbidity and mortality from cardiovascular disease. This is coupled with enhanced levels of thromboxane (TX), an eicosanoid that facilitates platelet aggregation. Although intensely studied, the mechanism underlyi...

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Détails bibliographiques
Auteurs principaux: Tang, Wai Ho, Stitham, Jeremiah, Gleim, Scott, Di Febbo, Concetta, Porreca, Ettore, Fava, Cristiano, Tacconelli, Stefania, Capone, Marta, Evangelista, Virgilio, Levantesi, Giacomo, Wen, Li, Martin, Kathleen, Minuz, Pietro, Rade, Jeffrey, Patrignani, Paola, Hwa, John
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204848/
https://ncbi.nlm.nih.gov/pubmed/22005299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59291
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