Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane

Diabetes mellitus is associated with platelet hyperactivity, which leads to increased morbidity and mortality from cardiovascular disease. This is coupled with enhanced levels of thromboxane (TX), an eicosanoid that facilitates platelet aggregation. Although intensely studied, the mechanism underlyi...

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Detalhes bibliográficos
Main Authors: Tang, Wai Ho, Stitham, Jeremiah, Gleim, Scott, Di Febbo, Concetta, Porreca, Ettore, Fava, Cristiano, Tacconelli, Stefania, Capone, Marta, Evangelista, Virgilio, Levantesi, Giacomo, Wen, Li, Martin, Kathleen, Minuz, Pietro, Rade, Jeffrey, Patrignani, Paola, Hwa, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204848/
https://ncbi.nlm.nih.gov/pubmed/22005299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59291
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