Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Chronic obstructive pulmonary disease (COPD), which is caused primarily by cigarette smoking, is a major health problem worldwide. The progressive decline in lung function that occurs in COPD is a result of persistent inflammation of the airways and destruction of the lung parenchyma. Despite the ke...

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Detalhes bibliográficos
Main Authors: Malhotra, Deepti, Thimmulappa, Rajesh K., Mercado, Nicolas, Ito, Kazuhiro, Kombairaju, Ponvijay, Kumar, Sarvesh, Ma, Jinfang, Feller-Kopman, David, Wise, Robert, Barnes, Peter, Biswal, Shyam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204828/
https://ncbi.nlm.nih.gov/pubmed/22005302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45144
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