Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects against Sepsis

Rationale: Sepsis syndrome is characterized by inappropriate amplified systemic inflammatory response and bacteremia that promote multiorgan failure and mortality. Nuclear factor–erythroid 2 p45-related factor 2 (Nrf2) regulates a pleiotropic cytoprotective defense program including antioxidants and...

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Bibliographic Details
Main Authors: Kong, Xiaoni, Thimmulappa, Rajesh, Craciun, Florin, Harvey, Christopher, Singh, Anju, Kombairaju, Ponvijay, Reddy, Sekhar P., Remick, Daniel, Biswal, Shyam
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208662/
https://ncbi.nlm.nih.gov/pubmed/21799073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201102-0271OC
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