Glutamine side chain at position 91 on the β5a-β5b loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase is required for stabilizing the dNTP binding pocket

Earlier, we postulated that Gln91 of HIV-1 RT stabilizes the side chain of Tyr183 via hydrogen bonding interaction between O(H) of Tyr183 and CO of Q91 (Harris et al., BIOCHEMISTRY 37: 9630, 1998). To test this hypothesis, we generated mutant derivatives of Gln91 and analyzed their biochemical prope...

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Библиографические подробности
Главные авторы: Pandey, Nootan, Mishra, Chaturbhuj A., Manvar, Dinesh, Upadhyay, Alok K., Talele, Tanaji T., Comollo, Thomas W., Kaushik-Basu, Neerja, Pandey, Virendra N.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204787/
https://ncbi.nlm.nih.gov/pubmed/21800837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200815e
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