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Glutamine side chain at position 91 on the β5a-β5b loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase is required for stabilizing the dNTP binding pocket
Earlier, we postulated that Gln91 of HIV-1 RT stabilizes the side chain of Tyr183 via hydrogen bonding interaction between O(H) of Tyr183 and CO of Q91 (Harris et al., BIOCHEMISTRY 37: 9630, 1998). To test this hypothesis, we generated mutant derivatives of Gln91 and analyzed their biochemical prope...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204787/ https://ncbi.nlm.nih.gov/pubmed/21800837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200815e |
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