Synthesis of phosphorothioate-containing DNA fragments by a modified hydroxybenzotriazole phosphotriester approach.

The phosphorothioylating agent which was obtained by treating 2,5-dichlorophenyl phosphorodichloridothioate with 1-hydroxy-6-nitrobenzotriazole proved to be very effective for the synthesis in solution and on a solid support of phosphorothioate-containing DNA fragments.

Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Marugg, J E, van den Bergh, C, Tromp, M, van der Marel, G A, van Zoest, W J, van Boom, J H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1984
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320440/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6549064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/12.23.9095
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