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Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy

PURPOSE: In temporal lobe epilepsy many somatostatin interneurons in the dentate gyrus die. However, some survive and sprout axon collaterals that form new synapses with granule cells. The functional consequences of GABAergic synaptic reorganization are unclear. Development of new methods to suppres...

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Hlavní autoři: Buckmaster, Paul S., Wen, Xiling
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204172/
https://ncbi.nlm.nih.gov/pubmed/21883182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2011.03253.x
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