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Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy

OBJECTIVE: In patients with temporal lobe epilepsy, seizures usually start in the hippocampus, and dentate granule cells are hyperexcitable. Somatostatin interneurons are a major subpopulation of inhibitory neurons in the dentate gyrus, and many are lost in patients and animal models. However, survi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Epilepsia
Hauptverfasser: Hofmann, Gabrielle, Balgooyen, Laura, Mattis, Joanna, Deisseroth, Karl, Buckmaster, Paul S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4903908/
https://ncbi.nlm.nih.gov/pubmed/27030321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13376
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