RNA Foci, CUGBP1, and ZNF9 Are the Primary Targets of the Mutant CUG and CCUG Repeats Expanded in Myotonic Dystrophies Type 1 and Type 2

Expansions of noncoding CUG and CCUG repeats in myotonic dystrophies type 1 (DM1) and DM2 cause complex molecular pathology, the features of which include accumulation of RNA aggregates and misregulation of the RNA-binding proteins muscleblind-like 1 (MBNL1) and CUG-binding protein 1 (CUGBP1). CCUG...

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Autors principals: Jones, Karlie, Jin, Bingwen, Iakova, Polina, Huichalaf, Claudia, Sarkar, Partha, Schneider-Gold, Christiane, Schoser, Benedikt, Meola, Giovanni, Shyu, Ann-Bin, Timchenko, Nikolai, Timchenko, Lubov
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2011
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204036/
https://ncbi.nlm.nih.gov/pubmed/21889481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.013
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