Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells

In embryonic stem cells (ESCs), Wnt-responsive development-related genes are silenced to maintain pluripotency and their expression is activated during differentiation. Acetylation of histones by histone acetyltransferases stimulates transcription, whereas deacetylation of histones by HDACs is corre...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lyu, Jungmook, Jho, Eek-hoon, Lu, Wange
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2011
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203701/
https://ncbi.nlm.nih.gov/pubmed/21423269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.47
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