Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells

In embryonic stem cells (ESCs), Wnt-responsive development-related genes are silenced to maintain pluripotency and their expression is activated during differentiation. Acetylation of histones by histone acetyltransferases stimulates transcription, whereas deacetylation of histones by HDACs is corre...

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Hlavní autoři: Lyu, Jungmook, Jho, Eek-hoon, Lu, Wange
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203701/
https://ncbi.nlm.nih.gov/pubmed/21423269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.47
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