Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation

Metazoan spliced leader (SL) trans-splicing generates mRNAs with an m(2,2,7)G-cap and a common downstream SL RNA sequence. The mechanism for eIF4E binding an m(2,2,7)G-cap is unknown. Here, we describe the first structure of an eIF4E with an m(2,2,7)G-cap and compare it to the cognate m(7)G-eIF4E co...

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Dettagli Bibliografici
Autori principali: Liu, Weizhi, Jankowska-Anyszka, Marzena, Piecyk, Karolina, Dickson, Laura, Wallace, Adam, Niedzwiecka, Anna, Stepinski, Janusz, Stolarski, Ryszard, Darzynkiewicz, Edward, Kieft, Jeffrey, Zhao, Rui, Jones, David N. M., Davis, Richard E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203607/
https://ncbi.nlm.nih.gov/pubmed/21965542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr650
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