Structural Insights into Parasite eIF4E Binding Specificity for m(7)G and m(2,2,7)G mRNA Caps

The eukaryotic translation initiation factor eIF4E recognizes the mRNA cap, a key step in translation initiation. Here we have characterized eIF4E from the human parasite Schistosoma mansoni. Schistosome mRNAs have either the typical monomethylguanosine (m(7)G) or a trimethylguanosine (m(2,2,7)G) ca...

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Detalhes bibliográficos
Main Authors: Liu, Weizhi, Zhao, Rui, McFarland, Craig, Kieft, Jeffrey, Niedzwiecka, Anna, Jankowska-Anyszka, Marzena, Stepinski, Janusz, Darzynkiewicz, Edward, Jones, David N. M., Davis, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781531/
https://ncbi.nlm.nih.gov/pubmed/19710013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049858
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