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Beta-globin mRNAs capped with m7G, m2.7(2)G or m2.2.7(3)G differ in intrinsic translation efficiency.

We examined the intramolecular effect of altered cap structures on translation efficiency of artificial beta-globin mRNAs. For these studies, synthetic dinucleotides of the form X(5')ppp(5')G [X = 7-methyl guanosine (m7G), 2,7-dimethyl guanosine (m2(2,7)G) or 2,2,7-trimethyl guanosine (m3(...

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Autores principales: Darzynkiewicz, E, Stepinski, J, Ekiel, I, Jin, Y, Haber, D, Sijuwade, T, Tahara, S M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1988
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC338645/
https://ncbi.nlm.nih.gov/pubmed/3174438
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