A Novel Nuclear Role for the Vav3 Nucleotide Exchange Factor in Androgen Receptor Coactivation in Prostate Cancer

Increased androgen receptor (AR) transcriptional activity mediated by coactivator proteins may drive castration resistant prostate cancer (CRPC) growth. Vav3, a Rho GTPase guanine nucleotide exchange factor (GEF), is over-expressed in human prostate cancers particularly in models of CRPC progression...

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Main Authors: Rao, Shuyun, Lyons, Leah S., Fahrenholtz, Cale D., Wu, Fayi, Farooq, Amjad, Balkan, Wayne, Burnstein, Kerry L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203328/
https://ncbi.nlm.nih.gov/pubmed/21765461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.273
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