A Novel Nuclear Role for the Vav3 Nucleotide Exchange Factor in Androgen Receptor Coactivation in Prostate Cancer

Increased androgen receptor (AR) transcriptional activity mediated by coactivator proteins may drive castration resistant prostate cancer (CRPC) growth. Vav3, a Rho GTPase guanine nucleotide exchange factor (GEF), is over-expressed in human prostate cancers particularly in models of CRPC progression...

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Détails bibliographiques
Auteurs principaux: Rao, Shuyun, Lyons, Leah S., Fahrenholtz, Cale D., Wu, Fayi, Farooq, Amjad, Balkan, Wayne, Burnstein, Kerry L.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203328/
https://ncbi.nlm.nih.gov/pubmed/21765461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.273
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