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A Novel Nuclear Role for the Vav3 Nucleotide Exchange Factor in Androgen Receptor Coactivation in Prostate Cancer

Increased androgen receptor (AR) transcriptional activity mediated by coactivator proteins may drive castration resistant prostate cancer (CRPC) growth. Vav3, a Rho GTPase guanine nucleotide exchange factor (GEF), is over-expressed in human prostate cancers particularly in models of CRPC progression...

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書誌詳細
主要な著者: Rao, Shuyun, Lyons, Leah S., Fahrenholtz, Cale D., Wu, Fayi, Farooq, Amjad, Balkan, Wayne, Burnstein, Kerry L.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203328/
https://ncbi.nlm.nih.gov/pubmed/21765461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.273
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