Coarse-grained modeling study of nonpeptide RGD ligand density and PEG molecular weight on the conformation of poly(γ-glutamyl-glutamate) paclitaxel conjugates

Molecular shape, flexibility, and surface hydrophilicity are thought to influence the ability of nanoparticles to cross biological barriers during drug delivery. In this study, coarse-grained (CG) molecular dynamics (MD) simulations were used to study these properties of a polymer-drug construct in...

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Detaylı Bibliyografya
Asıl Yazarlar: Peng, Lili X., Das, Sanjib K., Yu, Lei, Howell, Stephen B., Gough, David A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer-Verlag 2011
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203221/
https://ncbi.nlm.nih.gov/pubmed/21360176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00894-011-0989-4
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