Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence

The opportunistic human pathogenic fungus Aspergillus fumigatus is able to produce the dark brown pigment pyomelanin by degradation of L-tyrosine. Pyomelanin was shown to protect the fungus against reactive oxygen intermediates as well as cell wall disturbing compounds and is therefore assumed to pr...

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Bibliografiske detaljer
Main Authors: Keller, Sophia, Macheleidt, Juliane, Scherlach, Kirstin, Schmaler-Ripcke, Jeannette, Jacobsen, Ilse D., Heinekamp, Thorsten, Brakhage, Axel A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203155/
https://ncbi.nlm.nih.gov/pubmed/22046314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026604
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