The Role of Endosomal Escape and Mitogen-Activated Protein Kinases in Adenoviral Activation of the Innate Immune Response

Adenoviral vectors (AdV) activate multiple signaling pathways associated with innate immune responses, including mitogen-activated protein kinases (MAPKs). In this study, we investigated how systemically-injected AdVs activate two MAPK pathways (p38 and ERK) and the contribution of these kinases to...

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Detalhes bibliográficos
Main Authors: Smith, Jeffrey S., Xu, Zhili, Tian, Jie, Palmer, Donna J., Ng, Philip, Byrnes, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203151/
https://ncbi.nlm.nih.gov/pubmed/22046344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026755
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