Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli

Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide...

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Detalhes bibliográficos
Main Authors: Zeisel, Amit, Köstler, Wolfgang J, Molotski, Natali, Tsai, Jonathan M, Krauthgamer, Rita, Jacob-Hirsch, Jasmine, Rechavi, Gideon, Soen, Yoav, Jung, Steffen, Yarden, Yosef, Domany, Eytan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202801/
https://ncbi.nlm.nih.gov/pubmed/21915116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.62
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