Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenes such as K-ras mediate cellular and metabolic transformation during tumorigenesis. To analyze K-Ras-dependent metabolic alterations, we employed (13)C metabolic flux analysis (MFA), non-targeted tracer fate detection (NTFD) of (15)N-labeled glutamine, and transcriptomic profiling in mouse f...

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Main Authors: Gaglio, Daniela, Metallo, Christian M, Gameiro, Paulo A, Hiller, Karsten, Danna, Lara Sala, Balestrieri, Chiara, Alberghina, Lilia, Stephanopoulos, Gregory, Chiaradonna, Ferdinando
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202795/
https://ncbi.nlm.nih.gov/pubmed/21847114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.56
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