A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

Cancer cells share several metabolic traits, including aerobic production of lactate from glucose (Warburg effect), extensive glutamine utilization and impaired mitochondrial electron flow. It is still unclear how these metabolic rearrangements, which may involve different molecular events in differ...

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Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Damiani, Chiara, Colombo, Riccardo, Gaglio, Daniela, Mastroianni, Fabrizia, Pescini, Dario, Westerhoff, Hans Victor, Mauri, Giancarlo, Vanoni, Marco, Alberghina, Lilia
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634631/
https://ncbi.nlm.nih.gov/pubmed/28957320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005758
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