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Redesign of the PAK1 Auto-Inhibitory Domain for enhanced stability and affinity in biosensor applications
The inhibitory switch (IS) domain of p21-activated kinase 1 (PAK1) stabilizes full-length PAK1 in an inactive conformation by binding to the PAK1 kinase domain. Competitive binding of small GTPases to the IS domain disrupts the autoinhibitory interactions and exposes the IS domain binding site on th...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3202338/ https://ncbi.nlm.nih.gov/pubmed/21888918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.08.022 |
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