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3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers
The p21-activated kinase (PAK) family plays a versatile role in cell signaling by forming a hub of interactions. PAKs bind the GTPases like RAC and CDC42. Their proline-rich motifs bind SH3 adaptor proteins such as PIX and NCK. PAKs display nuclear localization signal sites and a potential Integrin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490965/ https://ncbi.nlm.nih.gov/pubmed/23162739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cl.21883 |
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