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An improved Protein G with higher affinity for human/rabbit IgG Fc domains exploiting a computationally designed polar network
Protein G is an IgG binding protein that has been widely exploited for biotechnological purposes. Rosetta protein modeling identified a set of favorable polar mutations in Protein G, at its binding interface with the Fc domain of Immunoglobulin G, that were predicted to increase the stability and ti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3966679/ https://ncbi.nlm.nih.gov/pubmed/24632761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzu005 |
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