B Cells Are Critical to T-cell-Mediated Antitumor Immunity Induced by a Combined Immune-Stimulatory/Conditionally Cytotoxic Therapy for Glioblastoma

We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumo...

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Autors principals: Candolfi, Marianela, Curtin, James F, Yagiz, Kader, Assi, Hikmat, Wibowo, Mia K, Alzadeh, Gabrielle E, Foulad, David, Muhammad, AKM G, Salehi, Sofia, Keech, Naomi, Puntel, Mariana, Liu, Chunyan, Sanderson, Nicholas R, Kroeger, Kurt M, Dunn, Robert, Martins, Gislaine, Lowenstein, Pedro R, Castro, Maria G
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201571/
https://ncbi.nlm.nih.gov/pubmed/22028620
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