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B Cells Are Critical to T-cell-Mediated Antitumor Immunity Induced by a Combined Immune-Stimulatory/Conditionally Cytotoxic Therapy for Glioblastoma

We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumo...

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Bibliografiske detaljer
Main Authors: Candolfi, Marianela, Curtin, James F, Yagiz, Kader, Assi, Hikmat, Wibowo, Mia K, Alzadeh, Gabrielle E, Foulad, David, Muhammad, AKM G, Salehi, Sofia, Keech, Naomi, Puntel, Mariana, Liu, Chunyan, Sanderson, Nicholas R, Kroeger, Kurt M, Dunn, Robert, Martins, Gislaine, Lowenstein, Pedro R, Castro, Maria G
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201571/
https://ncbi.nlm.nih.gov/pubmed/22028620
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