BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is induced by the oncogenic BCR-ABL1 tyrosine kinase and can be effectively treated for many years with tyrosine kinase inhibitors (TKIs). However, unless CML patients receive life-long TKI treatment, leukemia will eventually recur; this is attributed to the failure of...

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Autors principals: Hurtz, Christian, Hatzi, Katerina, Cerchietti, Leandro, Braig, Melanie, Park, Eugene, Kim, Yong-mi, Herzog, Sebastian, Ramezani-Rad, Parham, Jumaa, Hassan, Müller, Martin C., Hofmann, Wolf-Karsten, Hochhaus, Andreas, Ye, B. Hilda, Agarwal, Anupriya, Druker, Brian J., Shah, Neil P., Melnick, Ari M., Müschen, Markus
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2011
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201200/
https://ncbi.nlm.nih.gov/pubmed/21911423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110304
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